Healthy gut, healthy mind: The schizophrenia and digestion connection

If you’ve ever had a gut feeling that you are what you eat, new research suggests that you may be much closer to the mark than you think.

The role of the gut – dubbed our body’s most under-rated organ – briefly hit the popular consciousness with the international best-selling book, Gut, by micro-biologist Guilia Enders.

What is becoming clear in this rapidly evolving field of academic research is that our largest sensory organ – about eight metres long if laid end to end – has an intimate connection with our brain, and thus both with our mental health, our emotions and disorders such as schizophrenia.

Often called ‘the second brain’, the trillions of microbes that we carry in the gut produce the vast bulk of the same neuro-transmitters that are used for regulation of the brain. If the vagus nerve, which connects the brain and the digestive system, is cut, the digestive system functions fine on its own.

Enders writes that 10 years ago there was hardly any research linking the gut with the brain, where now there are several hundred academic articles. 
 

World-first study

Adding to that field of research is a project about to start at the Illawarra Health and Medical Research Institute at the University of Wollongong, headed by Dr Katrina Green and Professor Xu-Feng Huang, as well psychiatric Professor Nagesh Pai and psychologist Dr Jason Cusack.

The pilot project will study about 30 patients with schizophrenia to investigate the link between bacteria in our gut and brain functioning to identify new ways to improve cognitive function.

Source: University of Wollongong (from left)  1. Dr Katrina Green    2. Professor Xu-Feng Huang

 

“I find it fascinating that we get these gut feelings,” Dr Green says.

“When a person has a psychotic episode it’s in your face, so that’s what gets treated. The cognitive deficit that comes along with schizophrenia is in the background. 
 

Memory and learning loss

“Research is showing that cognitive deficit – problems with memory and learning – occurs in a lot of people before the first signs of the illness appear.

“I often hear that people’s sons or daughters are performing well at school, and then they go into a decline. By the time they are 19 or 20, they end up with psychosis.”

The project will not only look at ways of improving the brain functioning of those with schizophrenia, but also has the potential of providing early diagnosis for the disease.

The hypothesis of the study is that gut microbes are a key factor in the psychological changes in the brain.

The method will be to examine the gut microbes in the stool samples of patients, both when they are exhibiting symptoms of psychosis, and when they are not.

“Cognition is often not tested by clinicians and is not addressed by current anti-psychotic medications,” Dr Green says. 

Neuro-transmitters in the gut

These gut bacteria produce the same neuro-transmitters that regulate emotion and mental health in the brain – dopamine, serotonin, glutamate, norephinephrine.

“If we can find out what’s dysfunctional, then we can figure out how to fix it. The aim is to try and improve the functioning of people with schizophrenia and restore normality to their lives.”

Clinical psychologist Dr Jason Cusack is the researcher in charge with testing the cognition of the patients in the study.

As part of the Illawarra Brain Injury Service, he is experienced at administering tests to measure impairment of brain function, whether that’s from trauma or psychosis.

“The very interesting thing with schizophrenia and cognition is that it’s becoming more recognised as a core effect,” he says.

“Traditionally, the disease has been seen in terms of psychosis and hallucination, as well as the social factor of withdrawal. We have these negative symptoms of apathy, as well as the positive symptoms of psychosis.” 

Source: University of Wollongong (from left)  3. Dr Jason Cusack 4. Professor Nagesh Pai

Cognition is key

More recently, research and the most recent Diagnostic and Statistical Manual of Mental Disorders, published by the American Psychiatric Association, incorporates cognition as one of the key factors in schizophrenia.

Symptoms can include changes in memory and learning, perception and speech, distraction, inability to focus, depression, anxiety and a reduction in self-care.

For Professor Nagesh Pai, the research into the gut and its connection with mental health started in 2009; when he began researching why anti-psychotic drugs often caused weight-gain in patients.

Currently research is investigating a medication derived from lizard salvia; this medication is used   to counter the symptoms of diabetes. This medication has shown promise in mice with both weight loss and improvements in cognition; planning is under way for human trials. 
 

Huge effect on mental health

“We also know that patients with schizophrenia have two to three times the risk of developing diabetes, compared to the general population,” Dr Pai says.

“We are trying to find out the part that genetic factors play in this, as well as social or environmental factors. The aetiology of schizophrenia is multifactorial and while the role of genetic factors are well established further work is needed investigating the role of environmental and social factors in controlling diabetes in this population.

The UOW research team believe that altered gut microbes effect the neuronal functioning of the brain.

There is a lot of evidence that there is a bi-directional communication between the brain and the gut and that both influence the functioning of each other.

“If we are able to establish this, a new direction may be provided for the management of schizophrenia.”

 
Story By: William Verity 

Source: https://www.timeshighereducation.com/hub/university-wollongong (29/02/2024)

 

Writing by hand may increase brain connectivity more than typing, readings of student brains suggest

Writing by hand may increase brain connectivity more than typing, readings of student brains suggest

After recording the brain activity of university students, researchers in Norway determined that writing by hand may improve learning and memory.

A participant in the Norway study. Courtesy NTNU

Jan. 27, 2024, 4:00 PM IST

By Aria Bendix

Typing may be faster than writing by hand, but it’s less stimulating for the brain, according to research published Friday in the journal Frontiers in Psychology.

After recording the brain activity of 36 university students, researchers at the Norwegian University of Science and Technology determined that handwriting might improve learning and memory.

At the start of the experiment, the students were told to either write words in cursive using a digital pen on a touchscreen, or to type the same words using a keyboard. When a word such as “forest” or “hedgehog” appeared on a screen in front of them, they had 25 seconds to write or type it over and over.

Meanwhile, a cap of sensors on their head measured their brain waves. The cap’s 256 electrodes attached to the scalp and recorded the electrical signals of the students’ brains, including where brain cells were active and how parts of the brain communicated with each other.

“Our main finding was that handwriting activates almost the whole brain as compared to typewriting, which hardly activates the brain as such. The brain is not challenged very much when it’s pressing keys on a keyboard as opposed to when it’s forming those letters by hand,” said Audrey van der Meer, the study’s co-author and a neuropsychology professor at NTNU.

In particular, the study found that writing by hand required communication between the brain’s visual, sensory and motor cortices. People who wrote with the digital pen had to visualize letters, then use their fine motor skills to control their movement when writing.

“When you have to form letters by hand, an ‘A’ will look completely different than a ‘B’ and requires a completely different movement pattern,” van der Meer said.

By contrast, when typing, the keys look mostly the same, regardless of the letter. As a result, the study found, typing required less brain activity in the visual and motor cortices.

“Because only small parts of the brain are active during typewriting, there is no need for the brain to communicate between different areas,” van der Meer said.

Van der Meer’s previous research in children and young adults similarly found that people’s brains are more active while writing by hand than while typing. A 2017 study from Indiana University also indicated that writing by hand could link visual and motor skills, which might help kids better recognize letters.

But so far, there’s mixed evidence as to whether taking notes on paper versus a laptop can help people remember and understand information better in the classroom or raise their performance on tests.

It’s also hard to know whether or how the brain activity in the new study might translate into real-life improvements in learning or memory, said Ramesh Balasubramaniam, a neuroscientist at the University of California, Merced, who wasn’t involved in the research.

Source: https://www.nbcnews.com/health/health-news/writing-by-hand-may-increase-brain-connectivity-rcna135880 (DoA: 31/01/2024)

Income of workforce is linked to their height

Income of workforce is linked to their height

HRK News Bureau | New Delhi | Thursday, 16 August 2018

According to a World Bank report, two‐thirds of India’s current workforce was stunted in childhood and that's affecting their income.

171 million children under the age of five were stunted in the year 2014. According to the World Bank, this phenomenon, wherein children are excessively short for their age, is affecting their income levels.

Stunting in childhood is worrisome because it is associated with adverse outcomes throughout the life cycle. The undernourishment and disease that cause stunting impair brain development, leading to lower cognitive and socio-emotional skills, lower levels of educational attainment, and hence, lower incomes.

According to a World Bank report, two‐thirds of India’s current workforce was stunted in childhood.

Data reveals that on an average, an additional centimeter in height translates into 1.7 per cent higher wages in the labour market.

The rationale is that, had the stunted members of the current workforce not been stunted in childhood and attained regular height, they would not have suffered impaired cognitive development in their early years, nor would they have received less education.
Their income today would have been higher by a percentage that reflects the education penalty associated with childhood stunting, the returns to education, the adult height penalty to childhood stunting, the returns to height, the cognitive skills penalty to childhood stunting, and the returns to cognitive skills.

The average reduction of wages due to stunting for South Asia was 10 per cent, while that for North America was two per cent. The Middle East and North Africa do better, with a reduction of four per cent, compared to Europe and Central Asia with a reduction of five per cent.

© 2016 HR Katha

Source:(16/08/2018).

Mental Health Risks to Girls who Spend more than an Hour a Day on Social Media – New Study

Mental Health Risks to Girls who Spend more than an Hour a Day on Social Media – New Study

, March 20, 2018 5.13pm AEDT

Author: Cara Booker,

Research Fellow and Deputy Director of Graduate Studies, Institute for Social and Economic Research, University of Essex

For tweens and early teens, the rise in time spent on Snapchat, WhatsApp, Instagram and other social media is really quite dramatic. Culture minister Matt Hancock recently suggested the government could impose limits on the amount of time children spend on social media. In February, the House of Commons Science and Technology Select Committee launched a new inquiry to examine the health risks to children and young teens of increasing amounts of time on social media.
Our new study set out to look at patterns of behaviour among ten to 15 year olds in the UK, and their levels of well-being, to see if all this time spent online was having a detrimental impact on their mental health. We found that teenage girls are by far the highest users of social media, and those who are using it for more than an hour a day are also at the highest risk of developing well-being problems in later teen years.
We used the youth participants’ data from the UK household longitudinal study, Understanding Society, following almost 10,000 young people from diverse backgrounds across the whole country between 2009 and 2015.
We asked the young people to report on how much time they spent on social media on a “normal school day”. A few reported no internet access or no time spent at all, but some were on it for four hours or more. We found that 10% of ten-year-old girls reported spending one to three hours a day (compared with 7% of boys) and this increased to 43% of girls at age 15 (and 31% of boys).
We assessed two measures of well-being for these young people. The first was a combined score of their answers to questions about satisfaction with schoolwork, friends, family, appearance, school and life as a whole. The second measure was a well-established questionnaire which asked the young people about their social and emotional difficulties.
At age ten, girls who interacted on social media for an hour or more on a school day had worse levels of well-being compared to girls who had lower levels of social media interaction. Additionally, these girls with higher social media interaction at aged ten were more likely to experience more social and emotional difficulties as they got older. While our study was unable to say that the higher level of social media use among young girls directly caused the mental health issues, there was a strong association.
For both boys and girls, levels of happiness decreased between the ages of ten and 15, however the decrease among girls was greater than that of boys.

What makes girls different?

There are number of possible reasons why girls are more affected by social media use than boys. Girls participate in more comparisons of their own lives with those of the people they are friends with or follow. Viewing filtered or photoshopped images and mostly positive posts may lead to feelings of inadequacy and poorer well-being. Girls also feel more pressure to develop and maintain a social media presence than boys. Social media presence requires constant updating and having friends share or like their content. If their perceived popularity decreases over time, there may also be an increase in social and emotional difficulties.
Boys, on the other hand, are much more likely to participate in gaming online and via consoles than they are social media, and that wasn’t covered by our study. Boys’ levels of well-being may be more related to gaming.
So what can be done to help protect young people from the potential damage to their mental health? Social media interaction does not appear to be a short-lived phenomenon. A recent report by the Children’s Commissioner for England, Life in Likes, suggested imploring social media platforms to check underage use and preparing children better for life in a digital age. The recommendations did not discuss potential gender differences; but the findings from our study suggest that boys and girls can have varying responses to high levels of social media interaction.
There have also been calls for the technology industry to look at in-built time limits. Our study really backs this up – the amount of increasing time online is strongly associated with a decline in well-being among the young, especially for girls. Of course, young people need access to the internet for homework, for watching TV and to keep in touch with their mates. But they probably don’t need to spend two, three or four hours chatting, sharing and comparing on social media every school day. 
 

Source: http://theconversation.com/mental-health-risks-to-girls-who-spend-more-than-an-hour-a-day-on-social-media-new-study-93406 (20.03.2018)